Med1 | mediator complex subunit 1
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Reproductive system Integument Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging
12 No significant impact
5 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal placenta size | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| pallor | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| small superior vagus ganglion | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| hydrometra | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| pale yolk sac | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| enlarged uterus | 1 supporting dataset | Med1tm3b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Med1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Med1.
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| Med1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Med1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Med1tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Med1tm3b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Med1tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |